Synthesis,characterization, duplex-DNA interactions,and anticancer activities of novel octahedral [Ni(phen)2(dppz-idzo)]2+ and [Co(phen)2(dppz-idzo)]3+ complexes |
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| Authors: | Bahrouz Abulhasanov Ufuk Yıldız Senem Akkoç Burak Coban |
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| Institution: | 1. Department of Chemistry, Faculty of Arts and Sciences, Zonguldak Bulent Ecevit University, Zonguldak, 67100 Turkey;2. Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Suleyman Demirel University, Isparta, 32260 Turkey |
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| Abstract: | Two new octahedral Ni(phen)2(dppz-idzo)]2+ and Co(phen)2(dppz-idzo)]3+ complexes have been synthesized and characterized by CHN analysis, electrospray ionization-MS, nuclear magnetic resonance, and UV–Vis spectra. The DNA-binding ability of these complexes was spectrophotometrically, hydrodynamically, and electrophoretically evaluated which indicated that they strongly intercalate into the DNA double helix, and that both induced severe DNA damage in the presence of peroxide. The complexes also showed strong antiproliferative effect against HepG2 and MDA-MB-231 cells. By contrast, they were found to be inactive against the MCF-7 cell line. The ligand itself was found to be inactive against the cells tested. |
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| Keywords: | anticancer DNA binding dppz dppz-idzo phenazine |
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