Development of a new catalytic and sustainable methodology for the synthesis of benzodiazepine triazole scaffold using magnetically separable CuFe2O4@MIL-101(Cr) nano-catalyst in aqueous medium |
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Authors: | Ajay Gupta Fillip Kumar Sarkar Rajib Sarkar Ramen Jamatia Chang Yeon Lee Gajendra Gupta Amarta Kumar Pal |
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Institution: | 1. Department of Chemistry, Centre for Advanced Studies, North-Eastern Hill University, Shillong, 793022 India;2. Department of Energy and Chemical Engineering/Innovation Centre for Chemical Engineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon, 22012 Republic of Korea |
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Abstract: | Magnetically retrieval CuFe2O4@MIL-101(Cr) metal–organic framework was successfully prepared from easily available starting materials and characterized using various spectroscopic and analytical techniques such as powder X-ray diffraction, scanning electron microscopy, energy dispersive X-ray, transmission electron microscopy, elemental mapping, Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray photoelectron spectroscopy, Brunauer–Emmett–Teller, vibrating sample magnetometer, and inductively coupled plasma optical emission spectroscopy. The catalyst was then used in the synthesis of benzodiazepines containing a triazole moiety in water. The advantages of this protocol include high yields, reusability of the catalyst, and gram-scale synthesis. |
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Keywords: | benzodiazepine triazole scaffold CuFe2O4@MIL-101(Cr) gram-scale synthesis one-pot synthesis in aqueous medium recyclable catalyst |
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