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Sustainable synthesis of quinolines (pyridines) catalyzed by a cheap metal Mn(I)-NN complex catalyst |
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| Authors: | Huining Chai Weiqiang Tan Yuanyuan Lu Guangyao Zhang Jiping Ma |
| Institution: | 1. School of Environmental and Municipal Engineering, Qingdao University of Technology, 11 Fushun Road, Qingdao, 266033 China;2. Research Center for Intelligent and Wearable Technology, College of Textiles and Clothing, Qingdao University, Qingdao, 266071 China |
| Abstract: | This study represents the first example of a bidentate phosphine-free manganese(I)-NN complex catalyst for the synthesis of quinolines (pyridines) through acceptorless dehydrogenative condensation of various secondary alcohols with amino alcohols. The coupling reactions occurred at 3 mol% catalyst loading and 110°C, and tolerated diverse functional groups. Moderate to excellent yields ranging from 45% to 89% were achieved after 12 hr of reaction. The present protocol provides a concise and environmentally friendly method for the construction of heterocyclic compounds. |
| Keywords: | acceptorless dehydrogenative condensation manganese(I)-NN complex phosphine-free ligand quinolines (pyridines) |