| 甲卡西酮的液相色谱法测定 |
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| 引用本文： | 常颖,徐鹏,高利生.甲卡西酮的液相色谱法测定[J].化学分析计量,2012,21(1):67-69. |
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| 作者姓名： | 常颖 徐鹏 高利生 |
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| 作者单位： | 公安部物证鉴定中心,北京,100038 |
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| 摘 要： | 建立了高效液相色谱法测定甲卡西酮的含量。采用AgilentZorbax SB-Phenyl柱，流动相为三氟乙酸（pH3．51-乙腈（体积比85：15），流速0．2mL／min，检测波长254nm。甲卡西酮的浓度在0.5—1000μg／mL范围内与色谱峰面积呈良好的线性关系，F=0．999，日内与日间保留时间和峰面积测定结果的标对标准偏差均不大于1．48％（n=6），检出限为0．063μg／mL，平均加标回收率为118.2％。该方法适用于甲卡西酮的定性定量分析。
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| 关 键 词： | 高效液相色谱甲卡西酮定性定量 |
DETECTION OF METHCATHINONE BY HPLC |
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| Chang Ying
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Xu Peng
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Gao Lisheng.DETECTION OF METHCATHINONE BY HPLC[J].Chemical Analysis And Meterage,2012,21(1):67-69. |
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| Authors: | Chang Ying Xu Peng Gao Lisheng |
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| Institution: | ( Institute of Forensic Science Ministry of Public Security E R. C, Beijing 100038, China) |
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| Abstract: | A method was established for detecting methcathinone by HPLC. Agilent Zorbax SB-Phenyl column was used and the mobile phase was trifluoracetic acid （ pH 3.5 ） -acetonitrile （volum ratio was 85 ： 15） at a flow rate of 0.2 mL/min with 254 nm as the detection wavelength. The method had good linearity with the real value at the range of 0.5-1 000 μg/mL, r2=0.999. Both intra-day and inter-day precisions expressed by relative standard deviations of retention time and peak area were not more than 1.48%（n=6）. The detection limit was 0.063 μg/mL and recovery was 118.2%. This method was suitable for qualitative and quantitative analysis of methcathinone. |
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| Keywords: | HPLC methcathinone qualification quantification |
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