| 液相色谱法测定多元维生素片中4种水溶性维生素 |
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| 引用本文： | 盛灵慧,赵正宜,王晶,黄峥.液相色谱法测定多元维生素片中4种水溶性维生素[J].化学分析计量,2010,19(1):30-32. |
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| 作者姓名： | 盛灵慧 赵正宜 王晶 黄峥 |
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| 作者单位： | 中国计量科学研究院,北京,100013 |
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| 摘 要： | 采用高效液相色谱法测定多元维生素片中盐酸硫胺(B1)、核黄素(B2)、泛酸钙(B5)、盐酸吡哆醇(B6)的含量。重点考察了提取条件对于维生素测定的影响,4种维生素在确定的浓度范围内分别与色谱峰面积呈良好的线性关系,r2≥0.9999,加标回收率为99.2%～101.4%。4种维生素的检出限分别为0.30、0.19、0.45、0.11μg/g(S/N10)。该方法可作为实际测试标准方法使用。
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| 关 键 词： | 维生素B1 维生素B2 维生素B5 维生素B6 高效液相色谱 |
DETERMINATION OF SELECTED WATER-SOLUBLE VITAMINS IN TABLETS BY HPLC |
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| Sheng Linghui,Zhao Zhengyi,Wang jing,Huang Zheng.DETERMINATION OF SELECTED WATER-SOLUBLE VITAMINS IN TABLETS BY HPLC[J].Chemical Analysis And Meterage,2010,19(1):30-32. |
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| Authors: | Sheng Linghui Zhao Zhengyi Wang jing Huang Zheng |
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| Institution: | (National Institute of Metrology China, Beijing 100013, China) |
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| Abstract: | The HPLC method for determination of thiamine, riboflavin, calcium pantothenate, pyridoxine in muhielement tablets was established. The extraction process was optimized. In the fixed range of concentration, the method exhibited excellent linearity, r^2 ≥0.999 9. The recovery was 99.2% - 101.4%. The limits of quantifications （LOQ） of thiamine, riboflavin, calcium pantothenate, pyridoxine were 0.30, 0.19, 0.45, 0.11 μg/g （S/N 〉 10）, respectively. The method can be used as standard method in routine testing. |
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| Keywords: | vitamin B1 vitamin B2 vitamin B5 vitamin B6 HPLC |
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