| 液相色谱-串联质谱法测定动物性食品中20种抗生素类药物残留 |
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| 引用本文： | 赵华,卞永东,王德祥,汤勇,黄传国.液相色谱-串联质谱法测定动物性食品中20种抗生素类药物残留[J].化学分析计量,2011,20(1):20-24. |
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| 作者姓名： | 赵华 卞永东 王德祥 汤勇 黄传国 |
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| 作者单位： | 盐城市产品质量监督检验所,盐城市,224005 |
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| 摘 要： | 建立了一种专属、灵敏的方法用于同时检测动物性食品中β-内酰胺类青霉素类抗生素、大环内酯类抗生素、四环族抗生素和林可胺类共20 种抗生素药物残留.首先对动物性食品中的抗生素类药物进行提取,再经HLB固相萃取柱净化,采用电喷雾离子源,以正离子检测方式进行质谱分析.实验结果表明,在10-200 μg/L质量浓度范围内上述20...
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| 关 键 词： | 液相色谱-串联质谱法 动物性食品 抗生素药物 |
DETERMINATION OF 20 KINDS OF ANTIBIOTICS RESIDUES IN ANIMAL DERIVED FOOD BY LC-MS/MS |
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| Zhao hua,Bian Yongdong,Wang Dexiang,Tang Yong,Huang Chuanguo.DETERMINATION OF 20 KINDS OF ANTIBIOTICS RESIDUES IN ANIMAL DERIVED FOOD BY LC-MS/MS[J].Chemical Analysis And Meterage,2011,20(1):20-24. |
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| Authors: | Zhao hua Bian Yongdong Wang Dexiang Tang Yong Huang Chuanguo |
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| Institution: | Zhao hua,Bian Yongdong,Wang Dexiang,Tang Yong,Huang Chuanguo (Yancheng Quality Supervision and Test Institution of Products,Yanchen224005,China) |
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| Abstract: | A specific, sensitive method for detecting the residues about 20 kinds of β-1actam antibiotics in animal derived food was established. These antibiotics were β-lactam antibiotics, macrolide antibiotics, tetracycline antibiotics and Lincosamide antibiotics. First, antibiotics in animal foods were extracted, then purified by HLB solid phase extraction cartridges. Electro spray ionization and mass spectrometer were used to analyse these antibiotics by using positive ion. The experimental results showed that the 20 kinds of antibiotics had linearity as the concentrations in the range of 10 - 200μg/L with the correlation coefficient more than 0. 99. These 20 kinds of antibiotics were added in low, medium and high concentration, the average recoveries were 73.6% -114.6% and relative standard deviation was 1.1% - 12.0% （ n = 5 ）. The detection limits of 20 kinds of antibiotics were 0.5 - 10 μg/kg. |
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| Keywords: | liquid chromatography-tandem mass spectrometry(LC-MS /MS) animal derived food antibiotic |
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