Alcohol Dehydrogenases with anti-Prelog Stereopreference in Synthesis of Enantiopure Alcohols |
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| Authors: | Prof?Dr Musa M Musa |
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| Institution: | Department of Chemistry Interdisciplinary Research Center for Refining and Advanced Chemicals, King Fahd University of Petroleum and Minerals, Dhahran, 31261 Saudi Arabia |
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| Abstract: | Biocatalytic production of both enantiomers of optically active alcohols with high enantiopurities is of great interest in industry. Alcohol dehydrogenases (ADHs) represent an important class of enzymes that could be used as catalysts to produce optically active alcohols from their corresponding prochiral ketones. This review covers examples of the synthesis of optically active alcohols using ADHs that exhibit anti-Prelog stereopreference. Both wild-type and engineered ADHs that exhibit anti-Prelog stereopreference are highlighted. |
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| Keywords: | alcohol dehydrogenases anti-Prelog asymmetric reduction biocatalysis enantiopure alcohols |
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