Total Synthesis of Resveratrone and iso-Resveratrone |
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| Authors: | Stefan Fritsch Nazli Aldemir Jan Balszuweit Kevin Bojaryn Prof?Dr Jens Voskuhl Dr Christoph Hirschhäuser |
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| Institution: | Organic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitätsstr. 5–7, 45117 Essen, Germany |
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| Abstract: | The first total synthesis of resveratrone and iso-resveratrone based on an epoxide olefination approach is described. The pivotal reaction proceeds by insertion of the lithiated epoxide into a boronic ester and subsequent syn-elimination. Resveratrone has been described to have remarkable photophysical properties, including two-photon absorption. Therefore, an azide derivative has been prepared to allow for use as a biological label. |
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| Keywords: | epoxide fluorescence label olefination resveratrone total synthesis |
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