| 薄层原位荧光扫描测定锗-132制剂中倍半氧双羧乙基锗含量的研究 |
| |
| 引用本文： | 颜玉贞,谢培山,俞承明,沈美琴.薄层原位荧光扫描测定锗-132制剂中倍半氧双羧乙基锗含量的研究[J].分析测试学报,1991(4). |
| |
| 作者姓名： | 颜玉贞 谢培山 俞承明 沈美琴 |
| |
| 作者单位： | 广州市药品检验所
(颜玉贞，谢培山)，广州军区后勤卫生部药检所
(俞承明)，广州军区后勤卫生部药检所(沈美琴) |
| |
| 摘 要： | 本文报道由作者建立的薄层色谱法,样品在硅胶薄层板上展开后,以苯芴酮显色,再在碘钨灯下照射可使锗-132衍生成荧光化合物,从而可用原位荧光扫描(外标法)定量,已用于倍半氧双羧乙基锗(锗-132)原料和制剂的含量测定及稳定性研究。经3批原料、9批注射液、3批口服液样品的222个测试数据统计,C.V.值为2.29%,同板的C.V.值为1.5%～2.7%(n=7～10);加样回收率101.5%,最低检出限为0.12μg。
|
Quantitative Fluorodensitometric TLC Analysis of Organic Germanium |
| |
| YAN Yuzhen,XIE Peishan,YU Chengming,SHEN Meiqin Guangzhou Institute for Drug Control Guang Hou Iastitute of Materia Medica.Quantitative Fluorodensitometric TLC Analysis of Organic Germanium[J].Journal of Instrumental Analysis,1991(4). |
| |
| Authors: | YAN Yuzhen XIE Peishan YU Chengming SHEN Meiqin Guangzhou Institute for Drug Control Guang Hou Iastitute of Materia Medica |
| |
| Institution: | YAN Yuzhen;XIE Peishan;YU Chengming;SHEN Meiqin Guangzhou Institute for Drug Control Guang Hou Iastitute of Materia Medica |
| |
| Abstract: | Organic Germanium, also known as Ge-132, has been recent years introduced in China as anutritional supplement. For the need of quality control and stability, study a fluorodensitometric thinlayer chromatographic method for quantitative analysis of organic germanium has been establishedin our laboratory based on postchromatographic fluorescence derivatization with dipping the chro-matogram into phenylfluorone reagent, followed by irradiation under quartz halogen lamp. Theadvantages of this unprecedented TLC method over the conventional titration and atom absorptionare high sensitivity, good reliability and speciality. |
| |
| Keywords: | Organic germanium Ge-132 fluorodensitometric TLC quantitative analysis |
| 本文献已被 CNKI 等数据库收录！ |
