电感耦合等离子体质谱中的基质效应

电感耦合等离子体质谱(Inductively coupled plasma mass spectrometry,ICP-MS)是痕量元素分析中最常用的检测技术,尽管ICP-MS在元素分析中表现出诸多优势,但其在检测复杂基质样品时,仍会遇到许多问题。复杂基质所引起的基质效应通常会导致分析物信号的抑制或者增强。基质效应影响程度取决于基质成分的绝对浓度,还与基质的种类、分析物的物理和化学性质以及仪器条件有关。该文介绍了ICP-MS中几种常见的基质效应及其影响因素,包括元素基质、含碳基质、酸基质和仪器条件等,探究了基质效应产生的可能原因,对国内外去除基质效应的方法,如样品前处理方法、样品引入系统、优化仪器参数和校准法等进行了系统的归纳和总结,并对基质效应的研究进行了展望。

Matrix Effects in Inductively Coupled Plasma Mass Spectrometry

Inductively coupled plasma mass spectrometry(ICP-MS) is the most commonly used detection technique in trace element analysis.Although ICP-MS shows many advantages in elemental analysis,it still encounters many problems when samples with complex matrices are detected.Suppression or enhancement of the analyte signals is often observed in the presence of matrix effects.The degree of matrix effect depends not only on the absolute concentration of matrix components,but also on the type of matrix,the physical and chemical properties of the analyte and the instrument conditions.Several types of common matrix effects and the influencing factors in ICP-MS are introduced in this article,including elemental matrix,carbon contained matrix,acid matrix and instrument conditions,etc.The possible causes of matrix effects are explored.The methods for removing matrix effects,such as sample pretreatment methods,sample introduction system,instrument optimization and calibration methods etc.,are systematically summarized in this article.Besides,in the conclusion,the development tendency for analysis of matrix effects is also summarized and looked forward to.