| 八碳烯和十八碳烯与二乙烯基苯交联聚合包覆二氧化钛固定相的合成及反相色谱性能的评价 |
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| 引用本文： | 怀其勇,马庆林,左育民.八碳烯和十八碳烯与二乙烯基苯交联聚合包覆二氧化钛固定相的合成及反相色谱性能的评价[J].分析测试学报,2008,27(1):10-13,17. |
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| 作者姓名： | 怀其勇 马庆林 左育民 |
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| 作者单位： | 1. 山东大学,威海分校,海洋学院,山东,威海,264209
2. 南开大学,化学系,天津,300071 |
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| 摘 要： | 分别合成了八碳烯-1以及十八碳烯-1与二乙烯基苯交联聚合包覆二氧化钛固定相,对它们进行了元素分析和漫反射红外光潜的表征,并用这两种填料分离了稠环芳烃、烷基苯、苯胺类碱性化合物、卤代苯.实验证明这种交联聚合包覆崮定相对有机流动相和碱具有高稳定性.最后将两种固定相用于合成药中辛伐他汀和洛伐他汀的分离检测.
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| 关 键 词： | 二氧化钛 交联聚合包覆固定相 反相液相色谱 分离 固定相的稳定性 十八碳烯 二乙烯基苯 聚合包覆 二氧化钛 固定相 合成药 反相 色谱性能 评价 Evaluation Preparation HPLC Packing Titanium Dioxide 分离检测 洛伐他汀 辛伐他汀 高稳定性 流动相 验证 |
| 文章编号： | 1004-4957（2008）01-0010-05 |
| 收稿时间： | 2006-12-04 |
| 修稿时间： | 2007-01-27 |
Preparation and Evaluation of Co-polyoctene,Octadecene and Divinylbezene and Ethyl Styrene-encapsulated Titanium Dioxide Packing for HPLC |
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| HUAI Qi-yong,MA Qing-lin,ZUO Yu-min.Preparation and Evaluation of Co-polyoctene,Octadecene and Divinylbezene and Ethyl Styrene-encapsulated Titanium Dioxide Packing for HPLC[J].Journal of Instrumental Analysis,2008,27(1):10-13,17. |
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| Authors: | HUAI Qi-yong MA Qing-lin ZUO Yu-min |
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| Abstract: | The preparation of co-polyoctene, octadecene and divinylbezene and ethyl styrene-encapsulated titanium dioxide packing for HPLC and the characterization of the two new stationary phases using elemental analysis and diffuse reflection infrared spectrum were carried out. Good separations of polynuclear aromatic compounds, alkylbenzenes, basic aromatic compounds, halobenzenes as well as lovastatin and simvastatin were achieved. The high stability of C18- ES - DVB - TiO2 and C8 - ES - DVB -TiO2 to organic mobile phase and basic aqueous solution were also demonstrated. |
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| Keywords: | titanium dioxide polymer-encapsulated stationary phase reversed phase liquid chromatography separation stability of stationary phase |
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