| 正反相模式下键合纤维素手性固定相对手性化合物的拆分 |
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| 引用本文： | 韩小茜,李军,员春林,孙宇扬,王海生.正反相模式下键合纤维素手性固定相对手性化合物的拆分[J].分析测试学报,2007,26(1):55-58. |
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| 作者姓名： | 韩小茜 李军 员春林 孙宇扬 王海生 |
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| 作者单位： | 兰州交通大学,化学与生物工程学院,甘肃,兰州,730070 |
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| 基金项目： | 兰州交通大学“青蓝人才工程资助计划”资助项目，甘肃省教育厅资助项目(O316B-03)，甘肃省科技厅自然基金资助项目(32S042-B25-020) |
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| 摘 要： | 在自行合成的键合型纤维素-(3,5-二甲基苯基氨基甲酸酯)(CDMPC-CSP)手性固定相上,在正相模式下对苯偶姻和甲霜灵外消旋体进行了拆分,考察了流动相中醇以及温度在手性识别中对手性分离的影响。同时考察了反相模式下外消旋体的拆分。
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| 关 键 词： | 高效液相色谱 键合手性固定相 对映体拆分 |
| 文章编号： | 1004-4957（2007）01-0055-04 |
| 收稿时间： | 2006-01-10 |
| 修稿时间： | 2006-04-20 |
Chiral Separation of Compounds on Covalently Bonded Cellulose Chiral Stationary Phase by Normal and Reversed Phase HPLC |
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| HAN Xiao-qian,LI Jun,YUN Chun-lin,SUN Yu-yang,WANG Hai-sheng.Chiral Separation of Compounds on Covalently Bonded Cellulose Chiral Stationary Phase by Normal and Reversed Phase HPLC[J].Journal of Instrumental Analysis,2007,26(1):55-58. |
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| Authors: | HAN Xiao-qian LI Jun YUN Chun-lin SUN Yu-yang WANG Hai-sheng |
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| Institution: | The College of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China |
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| Abstract: | Two racemic compounds,benzoin and metalaxyl,were resolved by normal phase HPLC on self-synthetic cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase.The effects of different mobile phase compositions and the temperature of column on the retention,separation and resolution in the chiral separation of benzoin and metalaxyl were investigated.Moreover,the separation of the two racemic compounds under reversed HPLC was also studied. |
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| Keywords: | High performance liquid chromatography Bonded cellulose-based chiral stationary phase Enantioseparation |
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