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| 分子烙印聚合物为固定相分离和识别磺胺类药物 | |
| 引用本文： | 李莉,吴文镶,杨更亮.分子烙印聚合物为固定相分离和识别磺胺类药物[J].分析测试学报,2007,26(3):409-412. |
| 作者姓名： | 李莉 吴文镶 杨更亮 |
| 作者单位： | 1. 河北理工大学,轻工学院,河北,唐山,063020 2. 廊坊师范学院,继续教育中心,河北,廊坊,065000 3. 中国科学院化学研究所,北京,100080 |
| 基金项目： | 河北理工大学校科研和教改项目 |
| 摘 要： | 以磺胺甲噁唑为模板分子,采用原位聚合法制备了具有特定识别性能的棒状分子烙印聚合物。作为高效液相色谱的固定相实现了磺胺甲噁唑与其结构类似物的分离。磺胺甲噁唑烙印聚合物和目标分子之间的相互作用除了特异性的氢键作用外,也存在着疏水作用。同时考察含水量、流速对分离的影响,论证了分子烙印聚合物选择性专一的作用原理。结果表明,这种棒状聚合物对模板分子及其类似物有很好的分离能力。 |
| 关 键 词： | 原位聚合法 分子烙印 磺胺甲噁唑 固定相 分子烙印聚合物 |
| 文章编号： | 1004-4957（2007）03-0409-04 |
| 收稿时间： | 2006-05-08 |
| 修稿时间： | 2006-08-24 |
Molecularly Imprinted Polymer as Stationary Phase in HPLC for the Separation and Recognition of Sulfamethoxazole |
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| LI Li,WU Wen-xiang,YANG Geng-liang.Molecularly Imprinted Polymer as Stationary Phase in HPLC for the Separation and Recognition of Sulfamethoxazole[J].Journal of Instrumental Analysis,2007,26(3):409-412. | |
| Authors: | LI Li WU Wen-xiang YANG Geng-liang |
| Institution: | 1. Light Industry Branch, Hebei Polytechnic University, Tangshan 063020, China; 2. Center of Continued Education, Langfang Teachers College, Langfang 065000, China; 3. Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China |
| Abstract: | Sulfamethoxazole was used as a template for the in-situ preparation of molecular imprinted polymer(MIP) rods as stationary phases in HPLC for the separation and recognition of sulfamethoxazole and its analogues.It was found that the interactions between the MIP and target molecules were not only due to the hydrogen-bonding action but also due to hydrophobic interaction in the imprinted area.The effects of water content and flow rate on the separation were studied.Experimental results showed that the sulfamethoxazole imprinted polymer rod has specific selectivity and high affinity to sulfamethoxazole and its analogues. |
| Keywords: | In-situ polymerization method Molecular imprinting Sulfamethoxazole Stationary phase Molecularly imprinted polymer |
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