GC-MS/MS法对焙烤食品及其塑料包装材料中25种磷酸三酯类与邻苯二甲酸酯类化合物的同时测定

建立了气相色谱-质谱/质谱(GC-MS/MS)测定焙烤食品及其塑料包装材料中25种磷酸三酯类及邻苯二甲酸酯类化合物的高通量检测方法。焙烤食品以乙腈-丙酮(8∶2,体积比)超声提取,采用50 mg C18和50 mg PSA混合填料进行Qu ECh ERS净化;塑料包装材料经二氯甲烷-甲醇超声提取后直接检测。样液经DB-5 ms色谱柱分离,选择反应监测(SRM)模式测定。25种化合物在各自线性范围内的相关系数不小于0.997 5,方法检出限为10~500μg/kg,平均回收率为80.2%~119.6%,相对标准偏差(n=6)为1.5%~9.4%。该方法操作简单,净化效果好,可有效消除基质效应,适用于不同焙烤食品及其塑料包装材料中磷酸三酯类及邻苯二甲酸酯类化合物的同时测定。

Simultaneous Determination of 25 Organophosphate Esters and Phthalate Esters Compounds in Baked Foods and Plastic Packing Materials by GC-MS/MS

A high throughput method based on gas chromatography-triple quadrupole mass spectrometry(GC-MS/MS) was established for the determination of 25 kinds of organophosphate esters (OPEs) and phthalate esters(PAEs) compounds in baked foods and plastic packing materials.For baked foods,the samples were ultrasonically extracted with acetonitrile:acetone (8 ∶ 2,by volume),and then purified by QuEChERS with 50 mg C1s and 50 mg PSA.For plastic packaging materials,GC-MS/MS analysis was performed directly after dichloromethane-methanol extraction.All the samples were separated with a DB-5 ms chromatographic column,and detected in selected reaction monitoring (SRM) mode.The correlation coefficients for 25 compounds were not less than 0.997 5,and the method detection limits were in the range of 10-500 μg/kg.The average recoveries(n =6) ranged from 80.2％-119.6％ with the RSDs of 1.5％-9.4％.The developed method,with the advantages of easy operation,satisfactory purification effect and favorable matrix effect elimination capacity,was suitable for the determination of OPEs and PAEs in different kinds of baked foods and plastic packing materials.