相敏远程碳-氢相关技术在季碳归属中的应用

基于作者的二维相敏INEPT（insensitive nuclei enhanced by polarization transfer）实验，提出了相敏模式的远程碳－氢相关实验，称为相敏COLOC（heteronuclear correlation via logn-range couplings）实验，改善了远程碳－氢相关（COLOC）谱的分辨率。相敏COLOC实验可用于测定远程碳－氢相关信息，对季碳化学位移的归属具有一定的意义。作者给出了头孢呋辛钠的相敏COLOC谱。

Assignment of Quaternary Carbons by Phase-sensitive Heteronuclear Long-range Correlated Spectroscopy

Heteronuclear correlated spectroscopy in phase _ sensitive mode for determining long _ range couplings (phase _ sensitive COLOC) is proposed, which can be considered as a variant of phase _ sensitive 2D INEPT experiment for measuring heteronuclear long _ range coupling constants. With increased resolution as compared to the amplitude _ mode COLOC experiment, the phase _ sensitive COLOC experiment can be a useful technique for the assignment of quaternary carbons in organic compounds. A phase _ sensitive COLOC spectrum of cefuroxime sodium was given.