乳制品中兽药多种类残留的液相色谱-质谱分析研究进展

近年来,乳制品安全问题备受关注,兽药残留作为化学危害的一个重要部分使得针对其检测技术的研究一直是乳制品安全分析的热点领域,液相色谱-质谱技术因在灵敏度和选择性方面的优势已成为目前兽药残留分析的主流技术。基于液相色谱-质谱技术的兽药残留分析趋势已逐渐在向多种类、多组分发展,但由于兽药各种类之间在理化性质、残留状态、限量要求等方面差异较大,导致在样品前处理和仪器分析环节存在一定的技术困难。为进一步了解该技术领域的研究进展,该文从样品前处理、色谱-质谱检测和基质效应等方面对近几年采用液相色谱-质谱技术测定乳制品中兽药多种类残留的国内外文献进行了综述。

Research Progress on Liquid Chromatography-Mass Spectrometric Analysis of Multiclass Veterinary Drugs Residues in Dairy Products

More and more attention has been paid to the security of dairy products in recent years.Veterinary drug residue is an important part of chemical hazards so that the research on detection technology has always been a hotpot of dairy products' safety analysis.Liquid chromatography-mass spectrometry (LC-MS) has become a mainstream in veterinary drug residues analysis because of its special advantages of sensitivity and selectivity.The veterinary drug residues analysis based on LC-MS has been developed into multiclass and multiresidue stages gradually.While the differences of physicochemical properties,residual station and limited quantity exist among the multiclass veterinary drugs,both the sample pretreatment and subsequent instrument analysis have come across certain technological difficulties.To know more about the research development in this field,the literatures concerning the multiresidue determination of veterinary drugs in dairy products using LC-MS at home and abroad in resent years are summarized in this paper,from several aspects including sample pretreatment,LC-MS detection and matrix effect.