| 苯磺酸氨氯地平对映体在Chiralcel OJ柱上的色谱保留及拆分特性 |
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| 引用本文： | 唐晓丹,王绍艳,王智超,张伟.苯磺酸氨氯地平对映体在Chiralcel OJ柱上的色谱保留及拆分特性[J].分析测试学报,2011,30(1):34-37. |
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| 作者姓名： | 唐晓丹 王绍艳 王智超 张伟 |
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| 作者单位： | 辽宁科技大学分离技术中心;辽宁科技大学化学工程学院; |
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| 基金项目： | 辽宁省教育厅创新团队项目(2008T093) |
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| 摘 要： | 在Chiralcel OJ手性柱上对苯磺酸氨氯地平对映体进行分离研究.考察了在正己烷流动相体系中,不同碳数、不同立体结构的醇类添加剂以及不同醇含量对分离结果的影响,同时还考察了流速及柱温对分离的影响.并通过色谱保留及热力学行为研究对药物手性识别机理进行了探讨.结果表明,在正己烷-异丙醇(90:10,体积比)为流动相,流...
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| 关 键 词： | Chiralcel OJ柱 苯磺酸氨氯地平对映体 色谱保留 手性拆分 |
Chromatographic Retention and Separation Mechanism of Amlodipine Besylate Enantiomers on Chiralcel OJ Column |
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| TANG Xiao dan,WANG Shao yan,WANG Zhi chao,ZHANG Wei.Chromatographic Retention and Separation Mechanism of Amlodipine Besylate Enantiomers on Chiralcel OJ Column[J].Journal of Instrumental Analysis,2011,30(1):34-37. |
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| Authors: | TANG Xiao dan WANG Shao yan WANG Zhi chao ZHANG Wei |
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| Institution: | TANG Xiao-dan1,WANG Shao-yan2,WANG Zhi-chao2,ZHANG Wei1(1.Center of Separation Technology,University of Science and Technology Liaoning,Anshan 114051,China,2.School of Chemical Engineering,China) |
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| Abstract: | Enantioseparation of amlodipine besylate on Chiralcel OJ chiral column was studied.The influences of different carbon number,alcohol modifier types with different three-dimensional structures and concentrations,flow rate and column temperature on the enantioseparation of amlodipine besylate were investigated.And the chiral recognition mechanism for amlodipine was discussed by the chromatographic retention and thermodynamic parameters.A good baseline resolution was obtained for the separation of amlodipine b... |
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| Keywords: | Chiralcel OJ column amlodipine besylate enantiomers chromatographic retention chiral separation |
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