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聚苯乙烯凝胶色谱柱分离头孢呋辛钠聚合物杂质
引用本文:倪静文,魏荣卿,刘晓宁,方硕,袁耀佐,张玫.聚苯乙烯凝胶色谱柱分离头孢呋辛钠聚合物杂质[J].分析测试学报,2011,30(1):1-5.
作者姓名:倪静文  魏荣卿  刘晓宁  方硕  袁耀佐  张玫
作者单位:南京工业大学生物与制药工程学院色谱中心;江苏省药品检验所;
基金项目:“863”项目资助(2007AA02Z200)
摘    要:建立了聚苯乙烯基质的凝胶色谱柱系统对头孢呋辛钠中聚合物杂质(或称缩合物杂质)的分离分析方法.凝胶色谱柱为MKF-GPC-100柱(100 mm×7.8 mm,5 μm),流动相为0.01 mol/L的磷酸盐缓冲液(pH 7.0)-乙腈(70:30,体积比),流速1.0 mL/min,检测波长254 nm.头孢呋辛钠与其...

关 键 词:聚苯乙烯凝胶  MKF-GPC-100  头孢呋辛钠  缩合物杂质

Separation of Polymer Impurities in Cefuroxime Sodium by Polystyrene based Gel Filtration Chromatography
NI Jing wen,WEI Rong qing,LIU Xiao ning,FANG Shuo,YUAN Yao zuo,ZHANG Mei.Separation of Polymer Impurities in Cefuroxime Sodium by Polystyrene based Gel Filtration Chromatography[J].Journal of Instrumental Analysis,2011,30(1):1-5.
Authors:NI Jing wen  WEI Rong qing  LIU Xiao ning  FANG Shuo  YUAN Yao zuo  ZHANG Mei
Institution:NI Jing-wen1,WEI Rong-qing1,LIU Xiao-ning1,FANG Shuo1,YUAN Yao-zuo2,ZHANG Mei2(1.The Center of Chromatography,College of Biotechnology and Pharmaceutical Engineering,Nanjing University of Technology,Nanjing 210009,China,2.Jiangsu Institute for Drug Control,Nanjing 210008,China)
Abstract:A polystyrene-based gel filtration chromatographic method was established for the isolation and examination of condensation impurity in cefuroxime sodium.The sample was separated with MKF-GPC-100(100 mm×7.8 mm,5 μm) column uisng 0.01 mol/L phosphate buffer(pH 7.0)-acetonitrile(70∶30,by volume) as mobile phase.The flow rate was set at 1.0 mL/min and the detecting wavelength was set at 254 nm.The result indicated that the cefuroxime sodium was successfully separated from condensation impurity in 10 min.The method showed the advantages of simplicity and rapidness.
Keywords:polystyrene gel  MKF-GPC-100  cefuroxime sodium  condensation impurity  
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