| 姜黄素对人肝癌HepG2细胞毒性的分析 |
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| 引用本文： | 王牡,阮余霞,彭元,陈伟,蔡继业.姜黄素对人肝癌HepG2细胞毒性的分析[J].分析测试学报,2011,30(2):121-127. |
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| 作者姓名： | 王牡 阮余霞 彭元 陈伟 蔡继业 |
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| 作者单位： | 暨南大学化学系;暨南大学附属第一医院眼科; |
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| 基金项目： | 国家自然科学基金资助项目(30872404); “973计划”资助项目(2010CB/833603) |
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| 摘 要： | 该文结合倒置显微镜、原子力显微镜(AFM)、CCK-8和流式细胞术定性定量研究了姜黄素对人肝癌细胞株HepG2细胞的毒性.AFM探测结果表明,姜黄素能够引起细胞发生不同程度的形变.细胞体积和高度均随细胞形变程度的加深而下降.细胞表面平均粗糙度(Ra)、均方根粗糙度(Rq)和粒径分布均随细胞形变程度的加深而增大.而AFM...
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| 关 键 词： | 原子力显微镜 姜黄素 细胞毒性 表面粗糙度 粘附力 超微结构 |
Analysis of Curcumin Toxicity on Human Hepatoma HepG2 Cells |
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| WANG Mu,RUAN Yu xi,PENG Yuan,CHEN Wei,CAI Ji ye.Analysis of Curcumin Toxicity on Human Hepatoma HepG2 Cells[J].Journal of Instrumental Analysis,2011,30(2):121-127. |
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| Authors: | WANG Mu RUAN Yu xi PENG Yuan CHEN Wei CAI Ji ye |
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| Institution: | WANG Mu1,RUAN Yu-xia2,PENG Yuan1,CHEN Wei1,CAI Ji-ye1(1.Department of Chemistry,Jinan University,Guangzhou 510632,China,2.Department of Ophthalmology,The First Affiliated Hospital,China) |
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| Abstract: | Inverted microscope,atomic force microscope(AFM),CCK-8 and flow cytometer were used to study the toxicity of curcumin on human hepatoma HepG2 cells qualitatively and quantitatively.The AFM results indicated that curcumin could induce the deformation change of HepG2 cells to varying degrees.The volume and height of the cells decreased with the increase of cell deformation,whereas,the mean roughness(Ra),mean-square-root roughness(Rq) and granularity distribution of HepG2 cell surface increased with the increa... |
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| Keywords: | AFM curcumin cytotoxicity surface roughness adhesion force ultrastructure |
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