沙丁胺醇在SDBS现场自组装膜与［BnMIM］PF6复合修饰碳糊电极上的电催化氧化及电分析方法

研究了沙丁胺醇(SAL)在表面活性剂十二烷基苯磺酸钠(SDBS)现场自组装膜与离子液体1-苄基-3-甲基咪唑六氟磷酸盐(BnMIM]PF6)复合修饰碳糊电极(SDBS-BnMIM]PF6/CPE)上的电催化氧化行为和电化学动力学性质。实验结果表明,SDBS-BnMIM]PF6/CPE对SAL的电化学氧化具有良好的催化作用。用循环伏安法(CV)和计时电流法(CA)测得SAL在SDBS-BnMIM]PF6/CPE上的电极反应过程动力学参数。用方波伏安法(SWV)测得SAL氧化峰电流(Ipa)与其浓度在9.0×10-5～1.0×10-3mol.L-1范围内呈良好的线性关系,检出限(S/N=3)为1.08×10-6mol.L-1。运用该方法对市售吸入用沙丁胺醇溶液中SAL的含量进行了测定,结果满意。

Electrocatalytic Oxidation of Salbutamol at SDBS Self-assembled Monolayers and [ BnMIM ] PF6 Modified Carbon Paste Electrode and Its Electrochemical Determination

The electrocatalytic oxidation behaviors and electrochemical kinetics of salbutamol(SAL) were investigated at sodium dodecyl benzenesulfonate(SDBS) self-assembled monolayers and 1-benzyl-3-methylimidazole hexafluorophosphate(PF6) modified carbon paste electrode(SDBS-PF6/CPE).The experimental results indicated that the SDBS-PF6/CPE showed an excellent electrocatalytic activity toward SAL.The electrochemical kinetic parameters were determined by cyclic voltammetry(CV) and chronoamperometry(CA) at SDBS-PF6/CPE.The catalytic oxidation peak current of SAL versus its concentration had a good linear relationship in the concentration range of 9.0×10-5-1.0×10-3 mol·L-1 and the detection limit(S/N=3) was 1.08×10-6 mol·L-1 by square wave voltammetric(SWV) method.The proposed method was successfully applied in the electrochemical quantitative determination of SAL content in commercial inhaled salbutamol solution.