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The mathematical theory of molecular motor movement and chemomechanical energy transduction
Authors:Hong Qian
Institution:(1) Departments of Applied Mathematics and Bioengineering, University of Washington, Seattle, WA 98195, USA
Abstract:The mathematical formulation of the model for molecular movement of single motor proteins driven by cyclic biochemical reactions in an aqueous environment leads to a drifted Brownian motion characterized by coupled diffusion equations. In this article, we introduce the basic notion for the continuous model and review some asymptotic solutions for the problem. (For the lattice model see 17,47].) Stochastic, non-equilibrium thermodynamic interpretations of the mathematical equations and their solutions are presented. Some relevant mathematics, mainly in the field of stochastic processes, are discussed.
Keywords:augmented Huxley equation  probability circulation  entropy production  macromolecular mechanics  Markov process  nano-biochemistry  nonequilibrium steady-state  protein  singular perturbation  turning point
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