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Identifiability of chemical reaction networks
Authors:Gheorghe Craciun  Casian Pantea
Institution:(1) Department of Mathematics, University of Wisconsin-Madison, 480 Lincoln Drive, Madison, WI 53706-1388, USA;(2) Department of Biomolecular Chemistry, University of Wisconsin-Madison, 1300 University Avenue, Madison, WI 53706-1532, USA
Abstract:We consider the dynamics of chemical reaction networks under the assumption of mass-action kinetics. We show that there exist reaction networks $${\mathcal{R}}$$ for which the reaction rate constants are not uniquely identifiable, even if we are given complete information on the dynamics of concentrations for all chemical species of $${\mathcal{R}}$$ . Also, we show that there exist reaction networks $${\mathcal{R}}_1 \neq {\mathcal{R}}_2$$ such that their dynamics are identical under appropriate choices of reaction rate constants, and present theorems that characterize the properties of $${\mathcal{R}}$$ , $${\mathcal{R}}_1$$ , $${\mathcal{R}}_2$$ that make this possible. We use these facts to show how we can determine dynamical properties of some chemical networks by analyzing other chemical networks.
Keywords:Chemical reaction networks  Mass-action kinetics  Parameter identification
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