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Injectable and self-healing hydrogels with tissue adhesiveness and antibacterial activity as wound dressings for infected wound healing |
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| Authors: | Mengyuan Zhang Peiling Lin Xiaofan Song Kun Chen Yuxuan Yang Yongliang Xu Qiang Zhang Youshen Wu Yanfeng Zhang Yilong Cheng |
| Institution: | 1. School of Chemistry, Xi'an Jiaotong University, Xi'an, China
Contribution: Data curation (lead), Formal analysis (lead), Investigation (lead), Methodology (lead), Validation (lead), Visualization (equal), Writing - original draft (lead);2. School of Chemistry, Xi'an Jiaotong University, Xi'an, China Contribution: Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal), Validation (equal), Visualization (equal);3. School of Chemistry, Xi'an Jiaotong University, Xi'an, China Contribution: Data curation (equal), Formal analysis (equal), Methodology (equal), Validation (equal), Visualization (equal);4. School of Pharmacy, Xi'an Jiaotong University, Xi'an, China Contribution: Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal), Writing - original draft (supporting);5. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China Contribution: Data curation (equal), Formal analysis (supporting), Investigation (supporting), Methodology (supporting), Visualization (equal);6. ZhejiangYunFeng New Material Technology Co., Ltd, Jinhua, China Contribution: Formal analysis (supporting), Funding acquisition (supporting), Resources (supporting);7. School of Chemistry, Xi'an Jiaotong University, Xi'an, China Contribution: Funding acquisition (supporting), Methodology (supporting), Project administration (supporting), Supervision (supporting);8. School of Chemistry, Xi'an Jiaotong University, Xi'an, China Contribution: Funding acquisition (supporting), Methodology (supporting), Project administration (supporting), Supervision (supporting), Writing - original draft (supporting);9. School of Chemistry, Xi'an Jiaotong University, Xi'an, China Contribution: Funding acquisition (equal), Project administration (equal), Resources (equal), Supervision (equal), Writing - original draft (supporting);10. School of Chemistry, Xi'an Jiaotong University, Xi'an, China |
| Abstract: | The design of wound dressings with excellent self-healing ability, adequate adhesion, good biocompatibility, and potential antibacterial ability is of great significance for the healing of infected wounds arising from human activities. Herein, a series of multi-functional hydrogel dressings, poly(ionized isocyanoethyl methacrylate-glutamine)/poly(hexamethylene guanidine) (iGx/PHMGy) hydrogels, were obtained through homopolymerization of fully ionized isocyanoethyl methacrylate-glutamine (iIEM-Gln) in the presence of poly(hexamethylene guanidine) (PHMG), in which strong hydrogen bonds were formed among urea groups in the P (iIEM-Gln) chain to form a stable hydrogel network. The prepared iGx/PHMGy hydrogels exhibited adequate self-healing ability and tissue adhesion, which could be firmly adhered to the wound surface and remained intact during application. In addition, the presence of PHMG imparted good antibacterial activity to the hydrogels for the effective promotion of the wound healing in S. aureus infected skin wound on mice. Overall, this multi-functional hydrogel provides a facile and effective strategy for the design of infected wound dressings, and may show great potential in clinical applications. |
| Keywords: | antibacterial hydrogel infected wound self-healing wound dressing |