Self-assembled free-floating nanomaterials from sequence-defined polymers |
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Authors: | Jon Babi Linglan Zhu Angela Lin Azalea Uva Hana El-Haddad Atang Peloewetse Helen Tran |
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Institution: | Department of Chemistry, University of Toronto, Toronto, Ontario, Canada |
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Abstract: | Sequence-defined polymers can be programmed to self-assemble into precise nanostructures for applications in biosensing, drug delivery, optics, and molecular computation. Inspired by the natural self-assembly processes present in biological protein and DNA systems, sets of molecular design rules have emerged across materials classes as instructions to build a variety of tunable structures. This review highlights recent advances in self-assembled sequence-defined and sequence-specific polymers across peptides, peptoids, DNA, and non-biological synthetic materials, with a focus on synthesis, assembly processes and overall structure. Specifically, these self-assembled structures are free-floating, as such constructs can potentially serve as a platform for the aforementioned applications. Emphasis is placed on the molecular design of polymers that self-assemble into zero-dimensional, one-dimensional, two-dimensional, or three-dimensional nanostructures. With the development of automated syntheses and increasing control over self-assembly, future work may focus on emerging classes of compatible hybrid materials with exciting directions toward new architectures and applications. |
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Keywords: | DNA nanomaterials peptides peptoids polymers self-assembling sequence-defined |
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