| 2-氨基-4,6-二氯-5-甲酰氨基嘧啶的合成 |
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| 引用本文： | 贾志涛,张未星,杜娟,康宏杰.2-氨基-4,6-二氯-5-甲酰氨基嘧啶的合成[J].合成化学,2005,13(3):270-272,i003. |
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| 作者姓名： | 贾志涛 张未星 杜娟 康宏杰 |
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| 作者单位： | 浙江大学,材料与化工学院,浙江,杭州,310027;杭州三禾化工科技有限公司,浙江,杭州,310027 |
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| 摘 要： | 以丙二酸二乙酯和盐酸胍为起始原料，经环合、亚硝化、还原、氯化、水解得到2-氨基4，6-二氯-5-甲酰氨基嘧啶，总收率20％，其结构经61HNMR和IR表征。
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| 关 键 词： | 丙二酸二乙酯 氨基嘧啶 合成 |
| 文章编号： | 1005-1511(2005)03-0270-03 |
Synthesis of N-(2-amino-4,6-dichloro-5-pyrimidinyl)formamide |
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| JIA Zhi-tao,ZHANG Wei-xing,DU Juan,KANG Hong-jie.Synthesis of N-(2-amino-4,6-dichloro-5-pyrimidinyl)formamide[J].Chinese Journal of Synthetic Chemistry,2005,13(3):270-272,i003. |
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| Authors: | JIA Zhi-tao ZHANG Wei-xing DU Juan KANG Hong-jie |
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| Institution: | JIA Zhi-tao 1,ZHANG Wei-xing 1,DU Juan 2,KANG Hong-jie 2 |
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| Abstract: | N-(2-amino-4,6-dichloro-5-pyrimidinyl)formamide was synthesized from diethyl malonate and guanidine hydrochloride via cyclization, nitrosation, reduction, chloridization, hydrolysis with an overall yield of 20%. The structure was characterized by 1H NMR and IR. |
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| Keywords: | diethyl malonate amidepyrimidinyl synthesis |
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