| 异维A酸新木脂素酯的合成与表征 |
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| 引用本文： | 赵娜,邓小强,龙伯华,刘志常,袁国桂,向建南.异维A酸新木脂素酯的合成与表征[J].合成化学,2006,14(2):122-125. |
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| 作者姓名： | 赵娜 邓小强 龙伯华 刘志常 袁国桂 向建南 |
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| 作者单位： | 湖南大学,化学化工学院,湖南,长沙,410082 |
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| 基金项目： | 中国科学院资助项目
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浙江省湖州市自然科学基金 |
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| 摘 要： | 以香草醛(或对羟基苯甲醛)和丙二酸为原料,经Knoevenagel反应、酯化、氧化银为氧化剂的自由基仿生氧化偶联反应合成了新木脂素3a,3b。3a,3b分别与异维A酸酯化,合成了两种新型的异维A酸新木脂素酯4a和4b。用1H NMR,IR和MS对它们的结构进行了表征。研究了异维A酸酯的反应机理。
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| 关 键 词： | 异维A酸 新木脂素 合成 酯化 结构表征 |
| 文章编号： | 1005-1511（2006）02-0122-04 |
| 收稿时间： | 2005-09-14 |
| 修稿时间： | 2005年9月14日 |
Synthesis and Characterization of Neolignan-13-cis-Retinoates |
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| ZHAO Na,DENG Xiao-qiang,LONG Bo-hua,LIU Zhi-chang,YUAN Guo-gui,XIANG Jian-nan.Synthesis and Characterization of Neolignan-13-cis-Retinoates[J].Chinese Journal of Synthetic Chemistry,2006,14(2):122-125. |
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| Authors: | ZHAO Na DENG Xiao-qiang LONG Bo-hua LIU Zhi-chang YUAN Guo-gui XIANG Jian-nan |
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| Institution: | College of Chemistry and Chemical Engineering, Hunan University, Changsha 410092, China |
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| Abstract: | Neolignans(3a,3b) were synthesized via Knoevenagel reaction,esterification and Ag_2O-catalyzed biomimetic oxidative coupling from vanillin or p-hydroxylbezaldehyde and malonic acid.Two novel neolignan-13-cis-retinoates(4a,4b) were obtained by the reaction of 3a,3b with 13-cis-retinotic acid and their structures were characterized by ~1H NMR,IR and MS.The reaction mechanism of 13-cis-retinoate was studied. |
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| Keywords: | 13-cis-retinoic acid neolignan synthesis esterification characterization |
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