| MnCl_2催化交叉偶联合成沙坦联苯的工艺改进 |
| |
| 引用本文： | 张卫军,吴运东,刘西洋,李治章,向建南.MnCl_2催化交叉偶联合成沙坦联苯的工艺改进[J].合成化学,2009,17(3). |
| |
| 作者姓名： | 张卫军 吴运东 刘西洋 李治章 向建南 |
| |
| 作者单位： | 1. 湖南科技学院,湖南,永州,425100
2. 湖南大学,化学化工学院,湖南,长沙,410082 |
| |
| 基金项目： | 湖南省自然科学基金，湖南省科技厅基础研究支持项目，湖南省永州市科技局重点项目，湖南大学化学传感与生物计量学国家重点实验室资助项目 |
| |
| 摘 要： | 以对氯甲苯为原料,THF为溶剂,经 Grinard反应制得对甲苯基氯化镁格氏试剂,在MnCl2催化下格氏试剂与邻氯苯腈发生交叉偶联反应制得沙坦联苯,总收率80%,纯度大于99%.
|
| 关 键 词： | 沙坦联苯 交叉偶合反应 工艺改进 |
Process Improvenment on the Synthesis of Sartanbiphenyl by Cross-coupling Reaction Using MnCl_2 as a Catalyst |
| |
| ZHANG Wei-jun,WU Yun-dong,LIU Xi-yang,LI Zhi-zhang,XIANG Jian-nan.Process Improvenment on the Synthesis of Sartanbiphenyl by Cross-coupling Reaction Using MnCl_2 as a Catalyst[J].Chinese Journal of Synthetic Chemistry,2009,17(3). |
| |
| Authors: | ZHANG Wei-jun WU Yun-dong LIU Xi-yang LI Zhi-zhang XIANG Jian-nan |
| |
| Institution: | 1. Hunan University of Science and Engineering;Yongzhou 425100;China;2. College of Chemistry and Chemical Engineering;Hunan University;Changsha 410082;China |
| |
| Abstract: | Sartanbiphenyl was synthesized using MnCl2 as a catalyst by the cross coupling reaction of o-chlorobenzonitrile with p-MeC6H4MgCl,which was prepared from p-chlorotoluene in THF by a Grinard reaction. The total yield was 80% with purity over 99%. |
| |
| Keywords: | MnCl2 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
