|
|||||
|
|
| β-重氮-α-羰基酰胺类化合物的合成及其与烯烃的环丙烷化反应 | |
| 引用本文： | 陈晓娜,胡文浩,李小六,徐华栋.β-重氮-α-羰基酰胺类化合物的合成及其与烯烃的环丙烷化反应[J].合成化学,2012,20(1):19-22. |
| 作者姓名： | 陈晓娜 胡文浩 李小六 徐华栋 |
| 作者单位： | 1. 河北大学化学与环境科学学院,河北保定071002;华东师范大学小分子药物研究所,上海200062 2. 华东师范大学小分子药物研究所,上海,200062 3. 河北大学化学与环境科学学院,河北保定,071002 |
| 摘 要： | 以重氮丙酮酸乙酯和氨基醇为原料,经过氨解合成了一系列β-重氮-α-羰基酰胺类化合物,并与环己烯反应制备了环丙烷化产物,其结构经1H NMR,13C NMR,IR和HR-MS确证。 |
| 关 键 词： | 重氮丙酮酸乙酯 氨解 环己烯 环丙烷化 合成 |
Synthesis ofβ-Diazo-α-ketoamides and Their Cyclopropanation Reaction with Alkenes |
|
| CHEN Xiao-na , HU Wen-hao , LI Xiao-liu , XU Hua-dong.Synthesis ofβ-Diazo-α-ketoamides and Their Cyclopropanation Reaction with Alkenes[J].Chinese Journal of Synthetic Chemistry,2012,20(1):19-22. | |
| Authors: | CHEN Xiao-na HU Wen-hao LI Xiao-liu XU Hua-dong |
| Institution: | 1.College of Chemisty & Environment Science,Hebei University,Baoding 071002,China; 2.Institute of Drug Discovery and Development,East China Normal University,Shanghai 200062,China) |
| Abstract: | A series of chiral 2-oxo-3-diazo amide alcohol were synthesized from α-diazo-ethyl pyruvates and amino alcohols by the reaction of ammonolysis,their cyclo-propanation reactions with simple alkene to gave β-cyclopropyl-α-ketoamides bearing multiple handles for further chemical transformations.The structures were confirmed by 1H NMR,13C NMR,IR and HR-MS. |
| Keywords: | amino alcohol α-diazo-ethyl pyruvate ammonolysis cyclohexene cyclopropanation synthesis |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |