| Pd/C-甲酸铵在催化氢转移氢解反应中的应用 |
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| 引用本文： | 张莉莉,杲婷,宋琦,邱银华,林成刚,史海健.Pd/C-甲酸铵在催化氢转移氢解反应中的应用[J].合成化学,2012,20(3):366-368,371. |
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| 作者姓名： | 张莉莉 杲婷 宋琦 邱银华 林成刚 史海健 |
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| 作者单位： | 南京工业大学化学化工学院,江苏南京,210009 |
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| 基金项目： | 中国科学院上海有化学机研究所天然产物有机合成化学重点实验室研究基金资助项目 |
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| 摘 要： | 以Pd/C-甲酸铵为催化剂,沙美特罗的重要中间体1-(2,2-二甲基-4H-1,3-苯并二氧芑-6-基)-2-(2-羟基-1-苯乙氨基)乙醇通过催化氢转移氢解完成脱苄反应,收率92%。将Pd/C-甲酸铵应用于催化溴那维定脱溴制得加兰他敏的重要中间体那维定,收率75%。
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| 关 键 词： | 催化剂 钯/炭-甲酸铵 催化氢转移氢解反应 脱苄反应 脱溴反应 药物中间体 |
Application of Pd/C-( ammonium formate) in Catalytic Transfer Hydrogenolysis |
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| ZHANG Li-li
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GAO Ting
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SONG Qi
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QIU Yin-hua
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LIN Cheng-gang
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SHI Hai-jian.Application of Pd/C-( ammonium formate) in Catalytic Transfer Hydrogenolysis[J].Chinese Journal of Synthetic Chemistry,2012,20(3):366-368,371. |
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| Authors: | ZHANG Li-li GAO Ting SONG Qi QIU Yin-hua LIN Cheng-gang SHI Hai-jian |
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| Institution: | (College of Chemistry and Chemical Engineering,Nanjing University of Technology,Nanjing 210009,China) |
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| Abstract: | Using Pd/C-(ammonium formate) as the catalyst,an important intermediate of salmeterol,1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-(2-hydroxy-1-phenylethylamino)ethanol,was debenzylized by catalytic transfer hydrogenolysis in yield of 92%,and the important intermediate of galanthamine,narwedine,was obtained from bromonarwedine by debromination in yield of 75%. |
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| Keywords: | catalyst Pd/C-(ammonium formate) catalytic transfer hydrogenolysis debenzylation debromination drug intermediate |
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