| Diazepinomicin关键中间体三甲氧基二苯二氮平的合成 |
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| 引用本文： | 刘启洪,陈雷,万维李,吴勇.Diazepinomicin关键中间体三甲氧基二苯二氮平的合成[J].合成化学,2012,20(1):46-48. |
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| 作者姓名： | 刘启洪 陈雷 万维李 吴勇 |
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| 作者单位： | 四川大学华西药学院,四川成都,610041 |
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| 摘 要： | 以2,4-二甲氧基苯胺和3-甲基苯酚为原料,通过氨基保护、硝化、还原、甲基氧化、乌尔曼反应、内酰胺环化制得天然化合物Diazepinomicin的关键中间体——三甲氧基二苯二氮平,其结构经1H NMR,IR和MS表征.
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| 关 键 词： | diazepinomicin 二苯二氮平 药物中间体 合成 |
Synthesis of Key Intermediate of Diazepinomicin |
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| LIU Qi-hong
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CHEN Lei
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WAN Wen-li
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WU Yong.Synthesis of Key Intermediate of Diazepinomicin[J].Chinese Journal of Synthetic Chemistry,2012,20(1):46-48. |
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| Authors: | LIU Qi-hong CHEN Lei WAN Wen-li WU Yong |
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| Institution: | (West China School of Pharmacy,Sichuan University,Chengdu 610041,China) |
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| Abstract: | A key intermediate of natural compound diazepinomicin,4,6,8-trimethoxy-5H-dibenzodiazepinll(10H)-one,was synthesized from 2,4-dimethoxyaniline and 3-methylphenol by amino-protection,niration,reduction,oxidation,intermolecular Ullmann reaction and lactamization.The structrue was characterized by 1H NMR,IR and MS. |
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| Keywords: | diazepinomicin dibenzodiazepine drug intermediate synthesis |
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