| 双嘧达莫的合成工艺改进 |
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| 引用本文： | 张秋荣,蒋腾飞,王惠,邵坤鹏,刘宏民.双嘧达莫的合成工艺改进[J].合成化学,2012,20(2):257-259. |
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| 作者姓名： | 张秋荣 蒋腾飞 王惠 邵坤鹏 刘宏民 |
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| 作者单位： | 郑州大学药学院,河南郑州,450001 |
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| 基金项目： | 河南省科技研究项目基金资助 |
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| 摘 要： | 以乙酰乙酸乙酯为原料,与硫脲缩合成嘧啶环后,经硝化和氧化、硝基还原、与尿素缩合生成2,4,6,8-四羟基嘧啶5,4-d]并嘧啶,再经氯代、亲核取代等反应合成了抗血栓药双嘧达莫,总收率25.2%,其结构经1H NMR和HR-MS确证。
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| 关 键 词： | 双嘧达莫 抗血栓药物 药物合成 工艺改进 |
Process Improvement on the Synthesis of Dipyridamole |
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| ZHANG Qiu-rong
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JIANG Teng-fei
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WANG Hui
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SHAO Kun-peng
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LIU Hong-min.Process Improvement on the Synthesis of Dipyridamole[J].Chinese Journal of Synthetic Chemistry,2012,20(2):257-259. |
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| Authors: | ZHANG Qiu-rong JIANG Teng-fei WANG Hui SHAO Kun-peng LIU Hong-min |
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| Institution: | (School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China) |
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| Abstract: | Dipyridamole in total yield of 25.2% was synthesized by the condensation reaction of ethyl acetoacetate with thiourea,then nitration and oxidation,reduction,cyclization,chlorination,nucleophilic substitution.The structure was confirmed by 1H NMR and HR-MS. |
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| Keywords: | dipyridamole antithrombotic drugs drug synthesis process improvement |
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