| 常山酮中间体的合成工艺改进 |
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| 引用本文： | 王超杰,万阳,宋卫强,陆群.常山酮中间体的合成工艺改进[J].合成化学,2016,24(1):79-83. |
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| 作者姓名： | 王超杰 万阳 宋卫强 陆群 |
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| 作者单位： | 西南交通大学 生命科学与工程学院，四川 成都 610031 |
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| 基金项目： | 四川汪氏动物保健有限公司资助项目 |
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| 摘 要： | 以2-乙酰呋喃为起始原料，经扩环、甲基化、去质子化、亲核加成、缩酮化、Rh/C催化氢化及水解等反应合成了常山酮中间体--1-(3-甲氧基哌啶-2-基)丙酮，总收率40.2%，其结构经1H NMR和ESI-MS确证。
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| 关 键 词： | 2-乙酰呋喃 常山酮 中间体 1-(3-甲氧基哌啶-2-基)丙酮 合成 工艺改进 |
| 收稿时间： | 2015-01-14 |
Process Improvement on the Synthesis of Halofuginone Intermediate |
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| WANG Chao-jie,WAN Yang,SONG Wei-qiang,LU Qun.Process Improvement on the Synthesis of Halofuginone Intermediate[J].Chinese Journal of Synthetic Chemistry,2016,24(1):79-83. |
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| Authors: | WANG Chao-jie WAN Yang SONG Wei-qiang LU Qun |
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| Institution: | School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China |
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| Abstract: | Halofuginone intermediate, 1-(3-methoxypiperidin-2-yl)propan-2-one, was synthesized by ring-expansion, methylation, deprotonation, nucleophilic addition, ketalation, hydrogenation and hydrolysis, using 2-acetylfuran as the starting material. The overall yield was 40.2%. The structure was confirmed by 1H NMR and ESI-MS. |
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| Keywords: | 2-acetylfuran halofuginone intermediate 1-(3-methoxypiperidin-2-yl) propan-2-one synthesis process improvement |
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