| 新型香草醛缩苯并咪唑Schiff碱的合成及其抑菌活性 |
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| 引用本文： | 邓平,吴敏.新型香草醛缩苯并咪唑Schiff碱的合成及其抑菌活性[J].合成化学,2016,24(2):148-151. |
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| 作者姓名： | 邓平 吴敏 |
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| 作者单位： | 1. 玉林师范学院 生命科学与技术学院，广西 玉林 537000；2. 桂东南珍稀经济物种保护利用重点实验室培育基地，广西 玉林 537000 |
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| 基金项目： | 广西高校科学技术研究项目(KY2015LX304)，玉林师范学院科学研究项目(2014YJYB07) |
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| 摘 要： | 以邻苯二胺和香草醛为原料，合成了3个新型的香草醛缩苯并咪唑Schiff碱(5a~5c),其结构经1H NMR和IR表征。用菌丝生长速率法研究了5a~5c对小麦赤霉病菌(F.gra)，马铃薯干腐病菌(F.oxy)，玉米弯苞叶斑病菌(C.sor)，番茄早疫病菌(A.sol)和棉花枯萎病菌(F.oxy.s.v)的抑制活性。结果表明:香草醛缩2-甲基-5-氨基苯并咪唑（5c）对F.gra, F.oxy和C.sor的抑制活性高于多菌灵，其EC50值分别为19.76 mg·L-1， 24.94 mg·L-1和29.15 mg·L-1。
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| 关 键 词： | 苯并咪唑 希夫碱 合成 抑菌活性 |
| 收稿时间： | 2015-07-01 |
Synthesis and Antibacterial Activities of Novel Vanillin Benzimidazole Schiff Bases |
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| DENG Ping,WU Min.Synthesis and Antibacterial Activities of Novel Vanillin Benzimidazole Schiff Bases[J].Chinese Journal of Synthetic Chemistry,2016,24(2):148-151. |
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| Authors: | DENG Ping WU Min |
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| Institution: | 1. College of Life Science & Technology, Yulin Normal University, Yulin 537000, China; 2. Cultivation Base for Key Laboratory of Conservation and Utilization of Rare and Economic Species at Southeast, Yulin 537000, China |
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| Abstract: | Three novel vanillin benzimidazole Schiff bases(5a~5c) were synthesized, using o-phenylenediamine and vanillin as raw materials. The structures were characterized by 1H NMR and IR. The antibacterial activities of 5a~5c against Fusarium oxysporium(F.oxy), Alternaria solani(A.sol), Fusarium graminearum(F.gra), Cercospora sorghi(C.sor) and Fusaurium oxysporiumf. sp. vasinfectum(F.oxy) were investigated by mycelial growth rate method. The results indicated that 5c exhibited better antimicrobial activities against F.gra, F.ox and C.sor than Carbendazim with EC50 of 19.76 mg·L-1， 24.94 mg·L-1 and 29.15 mg·L-1. |
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| Keywords: | benzimidazole Schiff base synthesis antibacterial activity |
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