新型环己烯酮衍生物的合成

根据活性基团拼接原理，以烯草酮为先导化合物，通过修饰其肟醚位，引入具有除草活性的环苯草酮肟醚结构，设计并合成了一个新型的环己烯酮衍生物(7)。以对氯苯酚为原料，经取代、还原、卤代、肟醚化、水解等5步反应制得O-［2-(4-氯苯氧基)丙基］-羟胺盐酸盐(5); 5与5-［2-(乙硫基)丙基］-3-羟基-2-丙酰基-2-环己烯-1-酮反应合成了7，其结构经¹H NMR, ¹³C NMR, IR, ESI-MS和元素分析表征。

Synthesis of A Novel Cyclohexanedione Derivative

Herbicidal activity structure of profoxydim oxime-ether was introduced by modifying the ox-ime-ether structure of clethodim , according to the active-group combination principle .O-2-(4-chloro-phenoxy)propyl]-hydroxylamine hydrochloride(5)was obtained by substitution, reduction, halogena-tion, oxime etherification and hydrolysis , using p-chlorophenol as starting materials .A novel cyclohex-anediones derivative was designed and synthesized by the reaction of 5 with 5-2-( ethylthio) proplyl]-3-hydroxy-2-propionyl-2-cyclohexen-1-one.The structure was characterized by 1 H NMR, 13 C NMR, IR, ESI-MS and elemental analysis .