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| 甲状旁腺素1-34肽的固相合成 | |
| 引用本文： | 白振锋,刘全忠,田敏卿,马亚平.甲状旁腺素1-34肽的固相合成[J].合成化学,2007,15(3):388-390. |
| 作者姓名： | 白振锋 刘全忠 田敏卿 马亚平 |
| 作者单位： | 1. 西华师范大学,化学化工学院,四川,南充,637002 2. 中国科学院,海洋研究所,山东,青岛,266071 3. 深圳市翰宇生物工程有限公司,广东,深圳,518057 |
| 摘 要： | 以Wang树脂为固相载体,改进Fmoc(芴甲氧羰基)/tBu法,采用HPLC二次纯化,合成了甲状旁腺素1-34肽,产率23.3%,纯度大于99%(HPLC)。 |
| 关 键 词： | 甲状旁腺素 肽 Wang树脂 Fmoc/tBu法 固相合成 |
| 文章编号： | 1005-1511（2007）03-0388-03 |
| 收稿时间： | 2006-09-18 |
| 修稿时间： | 2007-03-06 |
Solid-phase Synthesis of N-Terminal 1-34 Peptide of Human Parathyroid Hormone |
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| BAI Zhen-feng,LIU Quan-zhong,TIAN Min-qing,MA Ya-ping.Solid-phase Synthesis of N-Terminal 1-34 Peptide of Human Parathyroid Hormone[J].Chinese Journal of Synthetic Chemistry,2007,15(3):388-390. | |
| Authors: | BAI Zhen-feng LIU Quan-zhong TIAN Min-qing MA Ya-ping |
| Institution: | 1. College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637000, China; 2. Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China;3. Shenzhen Hybio Engineering Co. , Ltd. , Shenzhen 518057, China |
| Abstract: | The human parathyroid hormone 1-34 peptide was synthesized on Wang resin in solid-phase by improving on Fmoc/tBu method.The peptide was purified twice by HPLC after cleavage and deprotection in 23.3% yield with purity higher than 99%. |
| Keywords: | parathyroid hormone peptide Wang resin Fmoc/tBu solid-phase synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |