| 血小板阻聚药物中间体N-环己基-5-氯丁基-1H-四氮唑的合成 |
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| 引用本文： | 贾义霞,高建荣,盛卫坚,俞开新.血小板阻聚药物中间体N-环己基-5-氯丁基-1H-四氮唑的合成[J].合成化学,2003,11(2):150-152. |
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| 作者姓名： | 贾义霞 高建荣 盛卫坚 俞开新 |
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| 作者单位： | 浙江工业大学化工学院精细化工研究所,浙江,杭州,310014 |
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| 摘 要： | 以δ-戊内酯和环己胺为原料合成了抗血小板聚集药物西洛他唑的重要中间体N-环己基-5-氯丁基-1H-四氮唑，选择了合适的相转移催化剂及安全的叠氮试剂并获得较高的收率。
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| 关 键 词： | 血小板阻聚药物 药物中间体 西洛他唑 N－环己基－5－氯丁基－lH－四氮唑 合成 δ－戊内酯 环己胺 |
Synthesis of N-cyclohexyl-5-(4'-chlorobutyl)-1H-tetrazole as an Important Intermediate of Platelet Aggregation Inhibitor Drugs |
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| Abstract.Synthesis of N-cyclohexyl-5-(4''-chlorobutyl)-1H-tetrazole as an Important Intermediate of Platelet Aggregation Inhibitor Drugs[J].Chinese Journal of Synthetic Chemistry,2003,11(2):150-152. |
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| Authors: | Abstract |
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| Abstract: | N-cyclohexyl-5-(4'-chlorobutyl)-1H-tetrazole was synthesized by a convenient process fromδ-valerolactone and cyclohexylamine. Appropriate cyclocondensation reagent and phase transfer catalyst were selected. The yield of product is 78%. The product is an important intermediate for producing drugs of blood platelets aggregation inhibitors. |
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| Keywords: | intermediate tetrazole cyclohexylamine platelet aggregation inhibitor drug synthesis |
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