| N-甲基-2-(4-取代哌嗪)-N-[3-(萘氧基)-3-(2-噻吩基)丙基]乙酰胺衍生物的设计与合成 |
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| 引用本文： | 郭磊,章文军,杨静.N-甲基-2-(4-取代哌嗪)-N-[3-(萘氧基)-3-(2-噻吩基)丙基]乙酰胺衍生物的设计与合成[J].合成化学,2010,18(2). |
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| 作者姓名： | 郭磊 章文军 杨静 |
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| 作者单位： | 河北工业大学,化工学院,天津,300130 |
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| 摘 要： | 以N-甲基-3-(1-萘氧基)-3-(2-噻吩基)-丙胺(度洛西汀)为原料,通过N-酰氯化反应和N-烷基化反应,合成了5个新型的N-甲基-2-(4-取代哌嗪)-N-3-(萘氧基)-3-(2-噻吩基)丙基]酰胺衍生物,其结构经1H NMR,IR和MS表征。
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| 关 键 词： | 取代哌嗪 度洛西汀 抗抑郁药 合成 |
Design and Synthesis of N-methyl-2-(4-acylpiperazin-1-yl)-N-[3-(naphthalene-1-yloxy)-3-(thiophen-2-yl)propyl]Acetamide Derivatives |
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| GUO Lei,ZHANG Wen-jun,YANG Jing.Design and Synthesis of N-methyl-2-(4-acylpiperazin-1-yl)-N-[3-(naphthalene-1-yloxy)-3-(thiophen-2-yl)propyl]Acetamide Derivatives[J].Chinese Journal of Synthetic Chemistry,2010,18(2). |
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| Authors: | GUO Lei ZHANG Wen-jun YANG Jing |
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| Abstract: | Five novel N-methyl-2-(4-acylpiperazin-1-yl)-N-3-(naphthalene-1-yloxy)-3-(thiophen-2-yl)propyl]acetamide derivatives were designed and synthesized from N-methyl-3-(naphthalene-1-yloxy)-3-(thiophen-2-yl)propan-1-amine by N-chloroacetylation and N-alkylation. The structures were characterized by ~1HNMR, IR and MS. |
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| Keywords: | Duloxetine substituted-piperzine antidepressant synthesis |
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