| 氟替卡松丙酸酯的合成 |
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| 引用本文： | 于国锋,高晓冲,高瑞昶,袁照勋,安志强.氟替卡松丙酸酯的合成[J].合成化学,2007,15(4):510-512,518. |
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| 作者姓名： | 于国锋 高晓冲 高瑞昶 袁照勋 安志强 |
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| 作者单位： | 1. 天津大学,化工学院,天津,300072
2. 石药集团,河北中润制药有限公司,河北,石家庄,050041 |
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| 摘 要： | 以双氟美松为原料,经氧化、酯化、酰化、醇解和氟甲基化反应制得氟替卡松丙酸酯(1),总收率60.1%。1和中间体的结构经1H NMR,IR和MS表征。
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| 关 键 词： | 氟替卡松丙酸酯 酰化 醇解 药物合成 |
| 文章编号： | 1005-1511（2007）04-0510-03 |
| 收稿时间： | 2006-12-12 |
| 修稿时间： | 2006-12-12 |
Synthesis of Fluticasone Propionate |
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| YU Guo-feng,GAO Xiao-chong,GAO Rui-chang,YUAN Zhao-xun,AN Zhi-qiang.Synthesis of Fluticasone Propionate[J].Chinese Journal of Synthetic Chemistry,2007,15(4):510-512,518. |
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| Authors: | YU Guo-feng GAO Xiao-chong GAO Rui-chang YUAN Zhao-xun AN Zhi-qiang |
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| Institution: | 1. College of Chemical Engineering, Tianjin University, Tianjin 300072, China; 2. Shijiazhuang Pharm Group, Hebei Zhongrun Pharmaceutical Co. , Ltd. , Shijiazhuang 050041, China |
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| Abstract: | Fluticason propionate(1) in overall yield of 60.1% was synthesized from Flumethasone by oxidation,esterification,acylation,alcoholysis and fluoromethylation.Their structure of 1 and intermediate were characterized by 1H NMR,IR and MS. |
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| Keywords: | Fluticasone propionate acylation alcoholysis drug synthesis |
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