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| 4-哌啶甲酸乙酯的合成 | |
| 引用本文： | 李永进,任国芬,王晓钟,陈英奇.4-哌啶甲酸乙酯的合成[J].合成化学,2007,15(4):513-515. |
| 作者姓名： | 李永进 任国芬 王晓钟 陈英奇 |
| 作者单位： | 1. 上虞三和医药化工有限公司,浙江,上虞,312369 2. 上虞市环境监测站,浙江,上虞,312369 3. 浙江大学,材料与化工学院,制药工程研究所,浙江,杭州,310027 4. 上虞三和医药化工有限公司,浙江,上虞,312369;浙江大学,材料与化工学院,制药工程研究所,浙江,杭州,310027 |
| 摘 要： | 以异烟酸为起始原料,经酯化和氢化还原反应制得药物中间体4-哌啶甲酸乙酯。酯化、氢化和总收率分别为84.6%,87%,75.4%。催化剂Pd/C可重复使用10次。 |
| 关 键 词： | 4-哌啶甲酸乙酯 非均相催化转移氢化反应 Pd/C 合成 |
| 文章编号： | 1005-1511（2007）04-0513-03 |
| 收稿时间： | 2006-11-08 |
| 修稿时间： | 2006-11-08 |
Synthesis of Ethyl 4-Piperidingcarboxylate |
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| LI Yong-jin,REN Guo-fen,WANG Xiao-zhong,CHEN Ying-qi.Synthesis of Ethyl 4-Piperidingcarboxylate[J].Chinese Journal of Synthetic Chemistry,2007,15(4):513-515. | |
| Authors: | LI Yong-jin REN Guo-fen WANG Xiao-zhong CHEN Ying-qi |
| Institution: | 1. Zhejiang Shangyu Sanhe Pharrnaehem Co. ,Ltd. , Shangyu 312369, China; Shangyu Environmental Protection Agency, Shangyu 312369, China; 3. Institute of Pharrnaeeutieal Engineering, College of Materials and Chemical Engineering, Zhejiang University, Hangzhou 310027, China |
| Abstract: | Ethyl 4-piperidingcarboxylate,which is an important intermediate,was synthesized from isonicotinic acid by esterification and hydrogenation.The yield of esterification,hydrogenation and the overall yield were 84.6%,87.0%,75.0%,respectively.The Pd/C can be reused 10 times. |
| Keywords: | ethyl 4-piperidingcarboxylate synthesis heterogeneous transfer hydrogenation Pd/C |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |