| 3-O-(β-D-吡喃葡萄糖-1-基)-6-(4-卤代苯基)哒嗪的合成与表征 |
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| 引用本文： | 辛炳炜,孙昌俊,曹晓冉,曲立强.3-O-(β-D-吡喃葡萄糖-1-基)-6-(4-卤代苯基)哒嗪的合成与表征[J].合成化学,2003,11(4):356-358. |
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| 作者姓名： | 辛炳炜 孙昌俊 曹晓冉 曲立强 |
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| 作者单位： | 1. 德州学院化学系,山东,德州,253023
2. 山东大学化学系,山东,济南,250100 |
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| 摘 要： | 利用6-(4-卤代苯基)-3(2H)-哒嗪酮的银盐(2)与2,3,4,6-四-O-乙酰基-1-溴-1-脱氧-α-D-吡喃葡萄糖(3)发生Koenigs-knorr反应,
合成了3-O-(2,3,4,6-四-O-乙酰基-β-D-吡喃葡萄糖-1-基)-6-(4-卤代苯基)哒嗪(4),4用干燥的氨气在0℃～-5℃下处理脱乙酰基保护基得相应的3-O-(β-D-吡喃葡萄糖-1-基)-6-(4-卤代苯基)哒嗪(5).其结构经元素分析,IR及1H
NMR证实.
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| 关 键 词： | 6-(4-卤代苯基)-3(2H)-哒嗪酮 葡萄糖苷 Koenigs-knorr反应 抗癌化合物 合成 |
The Synthesis and Characterization of 3-O-(β-D-glucopyranos-1-yl)-6-(4-halophenyl)pyridazines |
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| Abstract.The Synthesis and Characterization of 3-O-(β-D-glucopyranos-1-yl)-6-(4-halophenyl)pyridazines[J].Chinese Journal of Synthetic Chemistry,2003,11(4):356-358. |
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| Authors: | Abstract |
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| Abstract: | A synthesis of pyridazine glucosides is described. Condensation of 6-(4-halophenyl)-3(2H)-pyridazinone silver salt(2) with bromoacetylglucose(3) gave O-glucoside(4) by the Koenigs-Knorr reaction. Treatment of 4 with dry ammonia at 0℃～-5℃ effected a removal of the acetyl protecting groups to yield title compounds(5). Their structures were confirmed by elemental analysis, IR and 1H NMR. |
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| Keywords: | 6-(4-halophenyl)3(2H) pyridazinone glucoside Koenig's-Knorr reation antitumor compound synthesis |
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