| 3－N－取代－5－氟脲嘧啶的制备新方法 |
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| 引用本文： | 孙昌俊,李洪祥,王义贵,戚聿新,焦向华,张纪明,杨宇.3－N－取代－5－氟脲嘧啶的制备新方法[J].合成化学,1996(4). |
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| 作者姓名： | 孙昌俊 李洪祥 王义贵 戚聿新 焦向华 张纪明 杨宇 |
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| 作者单位： | 山东大学化学系，山东菏泽化工厂 |
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| 摘 要： | 报道了一种以Ｐｄ－Ｃ为催化剂，使２－苄氧基－３－Ｎ－取代－５－氟－４－嘧啶酮在室温常压下氢解制备３－Ｎ－取代－５－氟脲嘧啶的新方法，合成了８个３－Ｎ－取代－５－氟脲嘧啶化合物，其中有些化合物具有一定的抗肿瘤活性。
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| 关 键 词： | 5－氟脲嘧啶 氢解 抗癌化合物 合成 |
A New Method for Preparing 3-N-substituted-5-fluorouracils |
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| Sun ChangJun,Li HongXiang,Wang YiGui,Qi YuXin,Jiao Xiang-Hua,Zhang Ji-Ming,Yang Yu.A New Method for Preparing 3-N-substituted-5-fluorouracils[J].Chinese Journal of Synthetic Chemistry,1996(4). |
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| Authors: | Sun ChangJun Li HongXiang Wang YiGui Qi YuXin Jiao Xiang-Hua Zhang Ji-Ming Yang Yu |
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| Abstract: | In this paper,we report a new method for preparing 3-N-substituted-5-fluo rouracil from 2-benzyloxy-3-N-substituted-5-fluoro-4-pyrimidone and H_2 under normal pres sure at room temperature.Some compounds were synthesized in higher yield by this method.The preliminary results of the in vitro tests on HL-60 tumor cells showed that some of them are of certain antitumor activities. |
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| Keywords: | s:5-Fluorouracil Hydrogenolysis Andtumor compound Synthcsis |
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