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| 苯炔与硝酮[3+2]环加成制备二取代苯并异噁唑烷 | |
| 引用本文： | 仵清春,李保山,林文清,石常青,陈元伟,陈彦逍.苯炔与硝酮[3+2]环加成制备二取代苯并异噁唑烷[J].合成化学,2007,15(3):292-295. |
| 作者姓名： | 仵清春 李保山 林文清 石常青 陈元伟 陈彦逍 |
| 作者单位： | 1. 北京化工大学,理学院,北京,100029;中国科学院,成都有机化学研究所,四川,成都,610041 2. 北京化工大学,理学院,北京,100029 3. 中国科学院,成都有机化学研究所,四川,成都,610041 |
| 摘 要： | 采用3 2]1,3-偶极环加成反应,苯炔前体邻-三甲硅基苯酚三氟甲磺酸酯在氟化铯的作用下与硝酮反应合成了9个2,3-二取代苯并d]异噁唑烷,收率87%～97%。其结构经1H NMR,13C NMR和高分辨率MS确证。 |
| 关 键 词： | 邻-三甲硅基苯酚三氟甲磺酸酯 苯炔前体 硝酮 1 3-偶极环加成 苯并异噁唑烷 |
| 文章编号： | 1005-1511（2007）03-0292-04 |
| 收稿时间： | 2006-10-23 |
| 修稿时间： | 2006年10月23 |
Synthesis of 2,3-Disubstituted Benzo[d]isoxazolidines by [3+2] Cycloaddition Between Aryne and Nitrones |
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| WU Qing-chun,LI Bao-shan,LIN Wen-qing,SHI Chang-qing,CHEN Yuan-wei,CHEN Yan-xiao.Synthesis of 2,3-Disubstituted Benzo[d]isoxazolidines by [3+2] Cycloaddition Between Aryne and Nitrones[J].Chinese Journal of Synthetic Chemistry,2007,15(3):292-295. | |
| Authors: | WU Qing-chun LI Bao-shan LIN Wen-qing SHI Chang-qing CHEN Yuan-wei CHEN Yan-xiao |
| Institution: | 1. College of Science, Beijing University of Chemical Technology, Beijing 100029, China; 2. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China |
| Abstract: | In the presence of cesium fluoride,nine 2,3-disubstituted benzod]isoxazolidines in yields of 87%~97% were prepared by 1,3-dipolar 3 2] cycloaddition reaction between aryne precursor o-trimethylsilylphenyl triflate and a series of nitrones.Their structures were characterized by 1H NMR,13C NMR and high resolution MS. |
| Keywords: | o-trimethylsilylphenyl triflate aryne precusor nitrone 1 3-dipolar cycloaddition reaction benzo[d]isoxazolidine |
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