一种合成多氟联苯类化合物的新方法

以CuI为催化剂，芳胺与多氟苯经重氮化/偶联一锅反应生成了6个多氟取代的联苯类化合物(3a~3f)，收率56%~82%，其结构经¹H NMR， ¹⁹F NMR和EI-MS确证。在最佳反应条件［1a 2 mmol, 20%CuI为催化剂，150%四丁基碘化铵为碘化试剂，V(DMSO）:V（MeCN）=1 : 1为溶剂，于130 ℃反应4 h］下，3a收率75%。

A New Method for Synthesis of Multiple Fluorine Substituted Biaryl Compounds

A new one-pot synthetic method to prepare multiple fluorine substituted biaryl compounds (3a~3f) by diazotization/cross-coupling of aromatic anilines with polyfluoroarenes had been devel-oped.The yields were 56%~82%.The structures were confirmed by 1 H NMR, 19 F NMR and EI-MS.Under the optimized conditions1a 2 mmol, 20%CuI as the catalyst,150%Bu4 NI as the iodide reagent, V( DMSO) ∶V( MeCN)=1 ∶1 as the solvent, at 130 ℃for 4 h] , the yield of 3a was 75%.