| N-丁基-4-[乙基-(3-甲基苯基)氨基]丁酰胺的合成 |
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| 引用本文： | 丁成荣,魏一凡,刘宝国,季国炎.N-丁基-4-[乙基-(3-甲基苯基)氨基]丁酰胺的合成[J].合成化学,2017(1). |
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| 作者姓名： | 丁成荣 魏一凡 刘宝国 季国炎 |
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| 作者单位： | 1. 浙江工业大学 化学工程学院,浙江 杭州,310014;2. 绍兴东湖高科股份有限公司,浙江 绍兴,312074 |
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| 摘 要： | 以γ-丁内酯为起始原料,经开环氯化和酰化反应制得N-丁基-4-氯丁酰胺(2);2与N-乙基间甲苯胺经N-烷基化反应合成了N-丁基-4-乙基-(3-甲基苯基)氨基]丁酰胺,总收率74.6%,纯度97.6%,其结构经1H NMR和MS(ESI)确证。
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| 关 键 词： | γ-丁内酯 N-丁基-4-氯丁酰胺 N-丁基-4-乙基-(3-甲基苯基)氨基丁酰胺 合成 |
Synthesis of N-Butyl-4-[ ethyl(3-methylphenyl) amino] Butanamide |
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| DING Cheng-rong,WEI Yi-fan,LIU Bao-guo,JI Guo-yan.Synthesis of N-Butyl-4-[ ethyl(3-methylphenyl) amino] Butanamide[J].Chinese Journal of Synthetic Chemistry,2017(1). |
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| Authors: | DING Cheng-rong WEI Yi-fan LIU Bao-guo JI Guo-yan |
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| Abstract: | N-butyl-4-ethyl(3-methylphenyl) amino]-butanamide with the total yield of 74. 6% and the purity of 97 . 6% was synthesized by the reaction of N-ethyl-3-toluidine with N-butyl-4-chlorobutan-amide, which was synthesized through ring-opening chlorination and acylation reaction using 1,4-buty-rolactone as the starting material. The structure was confirmed by 1 H NMR and MS( ESI) . |
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| Keywords: | 1 4-butyrolactone N-butyl-4-chlorobutanamide N-butyl-4-[ethyl(3-methylphenyl)ami-no] butanamide synthesis |
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