| 用N-磺酰基Pictet-Spengler反应合成1,2,3,4-四氢异喹啉 |
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| 引用本文： | 倪峰,蒋慧慧,施小新.用N-磺酰基Pictet-Spengler反应合成1,2,3,4-四氢异喹啉[J].合成化学,2009,17(1). |
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| 作者姓名： | 倪峰 蒋慧慧 施小新 |
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| 作者单位： | 华东理工大学,药学院,制药工程系,上海,200237 |
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| 基金项目： | 国家自然科学基金，上海市教育发展基金 |
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| 摘 要： | 研究了在温和条件下,N-对甲苯磺酰基苯乙胺与各种醛之间的N-磺酰基Pictet-Spengler反应,成功地合成了一系列1,2,3,4-四氢异喹啉,其结构经1H NMR, IR, MS和元素分析表征.所用催化剂为各种路易斯酸或布朗斯特酸.
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| 关 键 词： | 苯乙胺 醛 Pictet-Spengler反应 催化 合成 |
Synthesis of 1,2,3,4-Tetrahydroisoquinoline by N-sulfonyl Pictet-Spengler Reaction |
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| NI Feng,JIANG Hui-hui,SHI Xiao-xin.Synthesis of 1,2,3,4-Tetrahydroisoquinoline by N-sulfonyl Pictet-Spengler Reaction[J].Chinese Journal of Synthetic Chemistry,2009,17(1). |
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| Authors: | NI Feng JIANG Hui-hui SHI Xiao-xin |
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| Institution: | School of Pharmacy;East China University of Science and Technology;Shanghai 200237;China |
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| Abstract: | 1,2,3,4-Tetrahydroisoquinolines were synthesized by Pictet-Spengler reaction of N-tosyl-phenethylamine with aldehydes under mild reaction conditions using Lewis acids or Brownst acids as catalysts.The structures were characterized by 1H NMR,IR,MS and elemental analysis. |
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| Keywords: | phenethylamine aldehyde Pictet-Spengler reaction catalysis synthesis |
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