| 一锅法合成新型异吲哚啉酮衍生物 |
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| 引用本文： | 张亚明,张燕霞,伍鹏程,柳军玺,魏小宁.一锅法合成新型异吲哚啉酮衍生物[J].合成化学,2020,28(3):188-193. |
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| 作者姓名： | 张亚明 张燕霞 伍鹏程 柳军玺 魏小宁 |
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| 作者单位： | 1. 中国科学院 兰州化学物理研究所 中国科学院西北特色植物资源化学重点实验室 甘肃省天然药物重点实验室，甘肃 兰州 730000； 2. 中国科学院大学，北京 100049 |
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| 摘 要： | 以二价铜为催化剂，邻溴苯甲酸、苯乙炔和伯胺为原料，经一锅法合成了12个以异吲哚啉酮为母核的新化合物，其结构经1H NMR, 13C NMR 和HR-MS(ESI)表征。并对催化机理进行了探讨。
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| 关 键 词： | 三组分反应 一锅法 合成 异吲哚啉酮衍生物 杂环取代 |
| 收稿时间： | 2018-12-05 |
Synthesis of Novel Isoindolin-1-ones Derivatives Through An One-pot Method |
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| ZHANG Ya-ming,ZHANG Yan-xia,WU Peng-cheng,LIU Jun-xi,WEI Xiao-ning.Synthesis of Novel Isoindolin-1-ones Derivatives Through An One-pot Method[J].Chinese Journal of Synthetic Chemistry,2020,28(3):188-193. |
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| Authors: | ZHANG Ya-ming ZHANG Yan-xia WU Peng-cheng LIU Jun-xi WEI Xiao-ning |
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| Institution: | 1. Key Laboratory of Chemistry of Northwestern Plant Resources, CAS, Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China; 2.University of Chinese Academy of Sciences, Beijing 10049, China |
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| Abstract: | A new synthesis method of twelve new derivatives with isoindolinone as the core was constructed by one-pot method, using divalent bromobenzoic acid, phenylacetylene, primary amine as materials and divalent copper as catalyst. The structures were characterized by 1H NMR, 13C NMR and HR-MS(ESI). And the catalytic mechanism was proposed. |
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| Keywords: | three components reaction one-pot method synthesis isoindolin-1-ones derivative heterocyclic substitution |
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