新型2-吡啶苄基胺类罗丹明基活性小分子探针的合成

以罗丹明B和乙二胺为原料，通过缩合反应制得罗丹明酰乙二胺(1, Rhb)；然后以无水THF作溶剂，化合物1与三聚氯嗪发生亲核取代反应，得到罗丹明酰乙二胺-三聚氯嗪化合物(2, Rhbc)；最后在氮气氛围下，化合物2与N,N-二甲基吡啶胺反应合成了目标产物双(2 吡啶苄基) 胺罗丹明基小分子探针(3, Rhbd),其结构经¹H NMR、 IR、 HR-MS和元素分析表征。该探针可以识别Fe³⁺，检出限为30 nM。

Synthesis of A Novel 2-Pyridinylbenzylamine Rhodamine Based Small Molecule Probe

Rhodamine B and ethylenediamine are used as raw materials to prepare rhodamine ethdiamine(1,Rhb) by condensation reaction. Then, using anhydrous THF as a solvent, the nucleophilic substitution reaction of the compound 1 and the cyanuric chloride gives the rhodamine ethoxydiamine-trichloro azine compound(2, Rhbc). Finally, under the N2 atmosphere, the reaction of compound 1 and N,N-dimethylpyridinium to get the target product bis(2-pyridylbenzyl) amine rhodamine-based small molecule probe(3, Rhbd), and its structure was charactized to 1H NMR, IR, HR-MS and elemental analysis. The probe can recognize Fe3+ and the detection limit is 3 nM.