| 唑来膦酸合成方法的研究进展 |
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| 引用本文： | 杨清翠,孙晓红,刘源发,马海霞.唑来膦酸合成方法的研究进展[J].合成化学,2010,18(6). |
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| 作者姓名： | 杨清翠 孙晓红 刘源发 马海霞 |
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| 作者单位： | 西北大学化工学院化学研究所;西安建筑科技大学理学院; |
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| 摘 要： | 综述了唑来膦酸(1)合成方法的研究进展。重点介绍了以咪唑为原料合成1的工艺条件,讨论了不同工艺条件的优缺点。结果显示,通过优选相转移催化剂和溶剂能高收率地合成1。参考文献30篇。
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| 关 键 词： | 唑来膦酸 咪唑 合成方法 催化剂 综述 |
Research Progress on the Synthetic Methods of Zoledronic Acid |
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| YANG Qing-cui,SUN Xiao-hong,LIU Yuan-fa,MA Hai-xia.Research Progress on the Synthetic Methods of Zoledronic Acid[J].Chinese Journal of Synthetic Chemistry,2010,18(6). |
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| Authors: | YANG Qing-cui SUN Xiao-hong LIU Yuan-fa MA Hai-xia |
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| Institution: | YANG Qing-cui1,2,SUN Xiao-hong1,LIU Yuan-fa1,MA Hai-xia1(1.College of Chemical Engineering,Chemical Research Institute,Northwest University,Xi'an 710069,China,2.School of Science,Xi'an University of Architecture and Technology,Xi'an 710055,China) |
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| Abstract: | Research progress on the synthetic methods of zoledronic acid(1) was reviewed with 30 references.The technology conditions of synthesis of 1 from imidazole were mainly introduced.Advantages and disadvantages of different technological conditions were discussed.The results showed that 1 in high yield was synthesized by selective preference of the phase transfer catalyst and solvent. |
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| Keywords: | zoledronic acid imidazole synthetical method catalyst review |
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