| 3-氨基-4-腈基吡唑的合成 |
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| 引用本文： | 张书桥,刘艳丽,吴达俊.3-氨基-4-腈基吡唑的合成[J].合成化学,2002,10(2):170-171. |
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| 作者姓名： | 张书桥 刘艳丽 吴达俊 |
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| 作者单位： | 华东理工大学药物化工研究所,上海,200237 |
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| 摘 要： | 经两步反应全盛了3－氨基－4－腈基吡唑；丙二腈与原甲酸三乙酯反应得到乙氧亚甲基丙二腈；其产物再与水合肼反应得到3－氨基－4－腈基吡唑，总收率为68．3％。
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| 关 键 词： | 丙二腈 原甲酸三乙酯 水合肼 佐匹隆 合成 3－氨基－4－腈基吡唑 |
Synthesis of 3-Amino-4-cyanopyrazole |
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| ZHANG Shu qiao,LIU Yan li,WU Da jun.Synthesis of 3-Amino-4-cyanopyrazole[J].Chinese Journal of Synthetic Chemistry,2002,10(2):170-171. |
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| Authors: | ZHANG Shu qiao LIU Yan li WU Da jun |
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| Abstract: | Amino 4 cyanopyrazole has been synthesized by a convenient two step process. First malononitrile reacted with ethyl orthoformate to give ethoxymethylenemalononitrile, then 3 amino 4 cyanopyrazole was obtained through the reaction of ethoxymethylenemalononitrile with hydrazine hydrate. The overall yield was 68.3%. |
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| Keywords: | aminocyanopyrazole zaleplon malononitrile orthoformate hydrazine hydrate synthesis |
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