| 合成2-氟腺嘌呤的新方法 |
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| 引用本文： | 汪江节,孙小燕,陈建兵.合成2-氟腺嘌呤的新方法[J].合成化学,2007,15(4):506-507. |
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| 作者姓名： | 汪江节 孙小燕 陈建兵 |
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| 作者单位： | 池州师范专科学校,物理化学系,安徽,池州,247000 |
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| 基金项目： | 安徽省教育厅自然科学基金
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安徽省教育厅研究生基金资助项目 |
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| 摘 要： | 从2-氨基-6-氯嘌呤出发,通过叠氮化反应合成2-氨基-6-叠氮嘌呤(3),3在希曼反应中完成氟对氨基的取代得到2-氟-6-叠氮嘌呤(4),4的叠氮基被还原为氨基制备出目标化合物2-氟腺嘌呤,总收率39.3%。
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| 关 键 词： | 嘌呤 叠氮化 希曼反应 合成 |
| 文章编号： | 1005-1511（2007）04-0506-02 |
| 收稿时间： | 2006-06-23 |
| 修稿时间： | 2006-06-23 |
A New Method for the Synthesis of 2-Fluoroadenine |
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| WANG Jiang-jie,SUN Xiao-yan,CHEN Jian-bing.A New Method for the Synthesis of 2-Fluoroadenine[J].Chinese Journal of Synthetic Chemistry,2007,15(4):506-507. |
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| Authors: | WANG Jiang-jie SUN Xiao-yan CHEN Jian-bing |
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| Institution: | Department of Physical and Chemistry, Chizhou College, Chizhou 247000, China |
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| Abstract: | 2-Amino-6-azidopurine(3) was synthesized from 2-amino-6-chloropurine by azido-reaction.Amido in 3 was substituted by fluorine through Schiemann reaction to obtain 2-fluoro-6-azidopurine(4).2-Fluoroadenine in overall yield of 39.3% was prepared by reducing azido in 4 to amido. |
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| Keywords: | purine azido-reaction Schiemann reaction synthesis |
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